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| Baudelet, Paul-hubert; Gagez, Anne-laure; Berard, Jean-baptiste; Juin, Camille; Bridiau, Nicolas; Kaas, Raymond; Thiery, Valerie; Cadoret, Jean-paul; Picot, Laurent. |
| The glaucophyte Cyanophora paradoxa (Cp) was chemically investigated to identify pigments efficiently inhibiting malignant melanoma, mammary carcinoma and lung adenocarcinoma cells growth. Cp water and ethanol extracts significantly inhibited the growth of the three cancer cell lines in vitro, at 100 mu g.mL(-1). Flash chromatography of the Cp ethanol extract, devoid of c-phycocyanin and allophycocyanin, enabled the collection of eight fractions, four of which strongly inhibited cancer cells growth at 100 mu g.mL(-1). Particularly, two fractions inhibited more than 90% of the melanoma cells growth, one inducing apoptosis in the three cancer cells lines. The detailed analysis of Cp pigment composition resulted in the discrimination of 17 molecules, ten of... |
| Tipo: Text |
Palavras-chave: Pigments; Microalgae; Cyanophora paradoxa; Melanoma; Cancer; Apoptosis; Zeaxanthin; Cryptoxanthin. |
| Ano: 2013 |
URL: http://archimer.ifremer.fr/doc/00177/28818/27289.pdf |
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| Chilian,Javier; Verdugo,Isabel; Poblete,Fernando; Ruiz-Lara,Simón; Casaretto,José A; González,Enrique. |
| Simultaneous exposition to low temperature and high light radiation cause photoinhibition of photosynthetic apparatus, affecting the productivity and geographical distribution of agricultural crops. In several Solanaceous species, tolerance to low temperature stress in combination with high light has been associated with some stimulation in non-photochemical quenching (NPQ), which involved reorganization in light-harvesting complex (LHC) proteins. To study photosynthetic performance in Solanum lycopersicum L. and S. chilense (Dunal) Reiche, and to investigate transcriptional regulation of genes encoding LHC proteins and their involvement in the NPQ, plants of both species were exposed to low temperature (4 °C) and high light radiation (1300 /<mol m-2... |
| Tipo: Journal article |
Palavras-chave: Lipid-peroxidation; Photoinhibition; Photochemical quenching; Zeaxanthin. |
| Ano: 2011 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-58392011000400002 |
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| Juin, Camille; De Oliveira Junior, Raimundo Gonsalves; Fleury, Audrey; Oudinet, Chloe; Pytowski, Lior; Berard, Jean-baptiste; Nicolau, Elodie; Thiery, Valerie; Lanneluc, Isabelle; Beaugeard, Laureen; Prunier, Gregoire; Guedes Da Silva Almeida, Jackson Roberto; Picot, Laurent. |
| Zeaxanthin, an abundant carotenoid present in fruits, vegetables and algae was reported to exert antiproliferative activity and induce apoptosis in human uveal melanoma cells. It also inhibited uveal melanoma tumor growth and cell migration in nude mice xenograft models. Here we report that zeaxanthin purified from the rhodophyte Porphyridium purpureum (Bory) K.M.Drew & R.Ross, Porphyridiaceae, promotes apoptosis in the A2058 human melanoma cell line expressing the oncogenic BRAF V600E mutation. Zeaxanthin 40 μM (IC50) induced chromatin condensation, nuclear blebbing, hypodiploidy, accumulation of cells in sub-G1 phase, DNA internucleosomal fragmentation and activation of caspase-3. Western blot analysis revealed that zeaxanthin induced up-regulation... |
| Tipo: Text |
Palavras-chave: Cancer; Carotenoid; Melanoma; Microalgae; Phytoplankton; Zeaxanthin. |
| Ano: 2018 |
URL: http://archimer.ifremer.fr/doc/00444/55595/57227.pdf |
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